First, decide what climate you like. I always found I was happier in a warm climate. You may like the snow. Whatever that is, don't forget to make yourself happy first. Once that decision is made the rest is easy. Interview a couple realtors in the town you want to live in. It is important that you get a good feeling from them. You could be working together for quite some time!
I had a friend google the ten best places to live in the USA and within months he moved 3000 miles away and has never been happier!!
So the question is ; What is your favorite climate? Can you work remotely from home? Did you check out the schools in the area you want to live? How about googling the doctors you may need.